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Literature summary for 2.7.8.29 extracted from
- Phosphatidylserine synthase regulates cellular homeostasis through distinct metabolic mechanisms (2019), PLoS Genet., 15, e1008548 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | Q9VPD3 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| salivary gland | - |
Drosophila melanogaster | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PSS | - |
Drosophila melanogaster |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | PSS regulates cell growth, lipid storage and mitochondrial function. RNAi-induced decreased of expression reduces phosphatidylserine and depletes plasma membrane Akt. Loss of PSS by RNAi reduces cell size and causes ectopic lipid storage in Drosophila salivary gland. Overexpressing phosphatidylserine decarboxylase enhances the cell growth defect and suppresses the ectopic lipid storage phenotype of pss knockdown. The reduction of mitochondrial phosphatidylserine impairs mitochondrial protein import and mitochondrial integrity | Drosophila melanogaster |
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Release 2023.1 (January 2023)
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